View source for 6wk7


==Crystal Structure Analysis of a poly(thymine) DNA duplex==
<StructureSection load='6wk7' size='340' side='right'caption='[[6wk7]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wk7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WK7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.423&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AX2:1,3,5-TRIAZINE-2,4,6-TRIAMINE'>AX2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wk7 OCA], [https://pdbe.org/6wk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wk7 RCSB], [https://www.ebi.ac.uk/pdbsum/6wk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wk7 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The diversity of DNA duplex structures is limited by a binary pair of hydrogen-bonded motifs. Here we show that poly(thymine) self-associates into antiparallel, right-handed duplexes in the presence of melamine, a small molecule that presents a triplicate set of the hydrogen-bonding face of adenine. X-ray crystallography shows that in the complex two poly(thymine) strands wrap around a helical column of melamine, which hydrogen bonds to thymine residues on two of its three faces. The mechanical strength of the thymine-melamine-thymine triplet surpasses that of adenine-thymine base pairs, which enables a sensitive detection of melamine at 3 pM. The poly(thymine)-melamine duplex is orthogonal to native DNA base pairing and can undergo strand displacement without the need for overhangs. Its incorporation into two-dimensional grids and hybrid DNA-small-molecule polymers highlights the poly(thymine)-melamine duplex as an additional tool for DNA nanotechnology.

A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials.,Li Q, Zhao J, Liu L, Jonchhe S, Rizzuto FJ, Mandal S, He H, Wei S, Sleiman HF, Mao H, Mao C Nat Mater. 2020 Jul 13. pii: 10.1038/s41563-020-0728-2. doi:, 10.1038/s41563-020-0728-2. PMID:32661383<ref>PMID:32661383</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6wk7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: He H]]
[[Category: Jonchhe S]]
[[Category: Li Q]]
[[Category: Liu L]]
[[Category: Mandal S]]
[[Category: Mao C]]
[[Category: Mao H]]
[[Category: Rizzuto FJ]]
[[Category: Sleiman HF]]
[[Category: Wei S]]
[[Category: Zhao J]]