View source for 7dfy


==Novel motif for left-handed G-quadruplex formation==
<StructureSection load='7dfy' size='340' side='right'caption='[[7dfy]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7dfy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DFY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dfy OCA], [https://pdbe.org/7dfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dfy RCSB], [https://www.ebi.ac.uk/pdbsum/7dfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dfy ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

A novel minimal motif for left-handed G-quadruplex formation.,Das P, Winnerdy FR, Maity A, Mechulam Y, Phan AT Chem Commun (Camb). 2021 Mar 9;57(20):2527-2530. doi: 10.1039/d0cc08146a. PMID:33690751<ref>PMID:33690751</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7dfy" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Das P]]
[[Category: Maity A]]
[[Category: Mechulam Y]]
[[Category: Phan AT]]
[[Category: Winnerdy FR]]