View source for 7ol1


==The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.==
<StructureSection load='7ol1' size='340' side='right'caption='[[7ol1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ol1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OL1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ol1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ol1 OCA], [https://pdbe.org/7ol1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ol1 RCSB], [https://www.ebi.ac.uk/pdbsum/7ol1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ol1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q187A2_CLOD6 Q187A2_CLOD6] 
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== Publication Abstract from PubMed ==
In many prokaryotes, the first step of threonine metabolism is catalysed by the enzyme threonine dehydrogenase (TDH), which uses NAD(+) to oxidize its substrate to 2-amino-3-ketobutyrate. The absence of a functional TDH gene in humans suggests that inhibitors of this enzyme may have therapeutic potential against pathogens which are reliant on this enzyme. Here, TDH from Clostridium difficile has been cloned and overexpressed, and the X-ray structure of the apoenzyme form has been determined at 2.6 A resolution.

The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.,Adjogatse E, Bennett J, Guo J, Erskine PT, Wood SP, Wren BW, Cooper JB Acta Crystallogr F Struct Biol Commun. 2021 Aug 1;77(Pt 8):269-274. doi:, 10.1107/S2053230X21007135. Epub 2021 Jul 28. PMID:34341193<ref>PMID:34341193</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7ol1" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Clostridioides difficile]]
[[Category: Large Structures]]
[[Category: Cooper JB]]
[[Category: Guo J]]