View source for 7r96


==Self-Assembled 3D DNA Hexagonal Tensegrity Triangle==
<StructureSection load='7r96' size='340' side='right'caption='[[7r96]], [[Resolution|resolution]] 5.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7r96]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R96 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.68&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r96 OCA], [https://pdbe.org/7r96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r96 RCSB], [https://www.ebi.ac.uk/pdbsum/7r96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r96 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The tensegrity triangle motif utilizes Watson-Crick sticky end cohesion to self-assemble into a rhombohedral crystal lattice using complementary 5'-GA and 5'-TC sticky ends. Here, we report that using noncanonical 5'-AG and 5'-TC sticky ends in otherwise isomorphic tensegrity triangles results in crystal self-assembly in the P6(3) hexagonal space group as revealed by X-ray crystallography. In this structure, the DNA double helices bend at the crossover positions, a feature that was not observed in the original design. Instead of propagating linearly, the tilt between base pairs of each right-handed helix results in a left-handed superstructure along the screw axis, forming a microtubule-like structure composed of three double helices with an unbroken channel at the center. This hexagonal lattice has a cavity diameter of 11 nm and a unit cell volume of 886â¯000 A(3)-far larger than the rhombohedral counterpart (5 nm, 330â¯000 A(3)).

3D Hexagonal Arrangement of DNA Tensegrity Triangles.,Lu B, Vecchioni S, Ohayon YP, Sha R, Woloszyn K, Yang B, Mao C, Seeman NC ACS Nano. 2021 Oct 26;15(10):16788-16793. doi: 10.1021/acsnano.1c06963. Epub 2021 , Oct 5. PMID:34609128<ref>PMID:34609128</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 7r96" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Lu B]]
[[Category: Mao C]]
[[Category: Ohayon YP]]
[[Category: Seeman NC]]
[[Category: Sha R]]
[[Category: Vecchioni S]]