View source for 7rsi


==The cryo-EM map of KIF18A bound to KIFBP==
<StructureSection load='7rsi' size='340' side='right'caption='[[7rsi]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7rsi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RSI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rsi OCA], [https://pdbe.org/7rsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rsi RCSB], [https://www.ebi.ac.uk/pdbsum/7rsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rsi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KBP_HUMAN KBP_HUMAN] Goldberg-Shprintzen megacolon syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KBP_HUMAN KBP_HUMAN] Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.<ref>PMID:16225668</ref> <ref>PMID:20621975</ref> <ref>PMID:23427148</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
[Figure: see text].

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding.,Solon AL, Tan Z, Schutt KL, Jepsen L, Haynes SE, Nesvizhskii AI, Sept D, Stumpff J, Ohi R, Cianfrocco MA Sci Adv. 2021 Nov 19;7(47):eabj9812. doi: 10.1126/sciadv.abj9812. Epub 2021 Nov, 19. PMID:34797717<ref>PMID:34797717</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7rsi" style="background-color:#fffaf0;"></div>

==See Also==
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cianfrocco MA]]
[[Category: Haynes SE]]
[[Category: Jepsen L]]
[[Category: Nesvizhskii AI]]
[[Category: Ohi R]]
[[Category: Schutt KL]]
[[Category: Sept D]]
[[Category: Solon AL]]
[[Category: Stumpff J]]
[[Category: Tan Z]]