View source for 7uzt


==Crystal structure of the human astrovirus MLB1 capsid protein spike domain at 1.86-A resolution==
<StructureSection load='7uzt' size='340' side='right'caption='[[7uzt]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7uzt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Astrovirus_MLB1 Astrovirus MLB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UZT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uzt OCA], [https://pdbe.org/7uzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uzt RCSB], [https://www.ebi.ac.uk/pdbsum/7uzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uzt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B6UYJ1_9VIRU B6UYJ1_9VIRU] The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis.[RuleBase:RU363102]
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</StructureSection>
[[Category: Astrovirus MLB1]]
[[Category: Large Structures]]
[[Category: Delgado-Cunningham K]]
[[Category: DuBois R]]