View source for 7xxe


==Crystal structure of spFft3 C-terminal truncation==
<StructureSection load='7xxe' size='340' side='right'caption='[[7xxe]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7xxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XXE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.202&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xxe OCA], [https://pdbe.org/7xxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xxe RCSB], [https://www.ebi.ac.uk/pdbsum/7xxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xxe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FFT3_SCHPO FFT3_SCHPO] DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. Required for maintaining a heterochromatin chromatin structure at centromeres and subtelomeres by protecting these regions from euchromatin assembly. Enhances the nucleotide exchange activity of the pim1 guanine nucleotide exchange factor and abolishes histone-H3-mediated RanGAP inhibition. Involved in the construction of the centromeres.<ref>PMID:15317843</ref> <ref>PMID:18422602</ref> <ref>PMID:21437270</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Nan Z]]
[[Category: Tao J]]
[[Category: Yangao H]]