View source for 7xxh


==Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11==
<StructureSection load='7xxh' size='340' side='right'caption='[[7xxh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7xxh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XXH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AD:2-(METHYLSULFANYL)ADENOSINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>6AD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xxh OCA], [https://pdbe.org/7xxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xxh RCSB], [https://www.ebi.ac.uk/pdbsum/7xxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xxh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P2RY1_HUMAN P2RY1_HUMAN] Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref>PMID:9442040</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Han S]]
[[Category: Li B]]
[[Category: Tan Q]]
[[Category: Wu B]]
[[Category: Zhao Q]]