View source for 7zj3


==Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate==
<StructureSection load='7zj3' size='340' side='right'caption='[[7zj3]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zj3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZJ3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zj3 OCA], [https://pdbe.org/7zj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zj3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zj3 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TRIM2_HUMAN TRIM2_HUMAN] Charcot-Marie-Tooth disease type 2R. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TRIM2_HUMAN TRIM2_HUMAN] UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.[UniProtKB:Q9ESN6]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Esposito D]]
[[Category: Fraser J]]
[[Category: Garza-Garcia A]]
[[Category: Rittinger K]]