View source for 7zma


==Ketosynthase domain of module 4 from Brevibacillus Brevis orphan BGC11==
<StructureSection load='7zma' size='340' side='right'caption='[[7zma]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zma]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis_NBRC_100599 Brevibacillus brevis NBRC 100599]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZMA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zma OCA], [https://pdbe.org/7zma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zma RCSB], [https://www.ebi.ac.uk/pdbsum/7zma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zma ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C0ZGQ6_BREBN C0ZGQ6_BREBN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid precursors. The most versatile families of PKSs are organized as assembly lines of functional modules. Each module performs one round of precursor extension and optional modification, followed by directed transfer of the intermediate to the next module. While enzymatic domains and even modules of PKSs are well understood, the higher-order modular architecture of PKS assembly lines remains elusive. Here, we visualize a PKS bimodule core using cryo-electron microscopy and resolve a two-dimensional meshwork of the bimodule core formed by homotypic interactions between modules. The sheet-like organization provides the framework for efficient substrate transfer and for sequestration of trans-acting enzymes required for polyketide production.

The structure of a polyketide synthase bimodule core.,Tittes YU, Herbst DA, Martin SFX, Munoz-Hernandez H, Jakob RP, Maier T Sci Adv. 2022 Sep 23;8(38):eabo6918. doi: 10.1126/sciadv.abo6918. Epub 2022 Sep , 21. PMID:36129979<ref>PMID:36129979</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7zma" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Brevibacillus brevis NBRC 100599]]
[[Category: Large Structures]]
[[Category: Herbst DA]]
[[Category: Jakob RP]]
[[Category: Maier T]]
[[Category: Tittes YU]]