View source for 7zzq


==BcsH-BcsD 'beads-on-a-string' filament, local refine==
<StructureSection load='7zzq' size='340' side='right'caption='[[7zzq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zzq]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataeibacter_hansenii_ATCC_23769 Komagataeibacter hansenii ATCC 23769]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZZQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zzq OCA], [https://pdbe.org/7zzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zzq RCSB], [https://www.ebi.ac.uk/pdbsum/7zzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zzq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q76KJ6_NOVHA Q76KJ6_NOVHA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cellulose, the most abundant biopolymer on Earth, is not only the predominant constituent of plants but also a key extracellular polysaccharide in the biofilms of many bacterial species. Depending on the producers, chemical modifications, and three-dimensional assemblies, bacterial cellulose (BC) can present diverse degrees of crystallinity. Highly ordered, or crystalline, cellulose presents great economical relevance due to its ever-growing number of biotechnological applications. Even if some acetic acid bacteria have long been identified as BC superproducers, the molecular mechanisms determining the secretion of crystalline versus amorphous cellulose remain largely unknown. Here, we present structural and mechanistic insights into the role of the accessory subunits BcsH (CcpAx) and BcsD (CesD) that determine crystalline BC secretion in the Gluconacetobacter lineage. We show that oligomeric BcsH drives the assembly of BcsD into a supramolecular cytoskeletal scaffold that likely stabilizes the cellulose-extruding synthase nanoarrays through an unexpected inside-out mechanism for secretion system assembly.

Bacterial crystalline cellulose secretion via a supramolecular BcsHD scaffold.,Abidi W, Decossas M, Torres-Sanchez L, Puygrenier L, Letoffe S, Ghigo JM, Krasteva PV Sci Adv. 2022 Dec 16;8(50):eadd1170. doi: 10.1126/sciadv.add1170. Epub 2022 Dec , 16. PMID:36525496<ref>PMID:36525496</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7zzq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Komagataeibacter hansenii ATCC 23769]]
[[Category: Large Structures]]
[[Category: Abidi W]]
[[Category: Decossas M]]
[[Category: Krasteva PV]]