View source for 8bv8


==Crystal structure of the phage Mu protein Mom inactive mutant S124A==
<StructureSection load='8bv8' size='340' side='right'caption='[[8bv8]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8bv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_Mu Escherichia phage Mu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BV8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bv8 OCA], [https://pdbe.org/8bv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bv8 RCSB], [https://www.ebi.ac.uk/pdbsum/8bv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bv8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MOM_BPMU MOM_BPMU] Iron-binding protein that performs methylcarbamoylation of adenine using acetyl CoA (PubMed:32369169). This chemical modificaltion makes the viral DNA resistant to a variety of host type I and type II restriction enzymes by modifying approximately 15% of DNA adenine residues (PubMed:32369169). The modification called momylation changes adenine for N6-methylcarbamoyl adenine and occurs just before packaging (PubMed:1258376, PubMed:32369169). Target sequences are 5'-(C or G)-A-(Cor G)-N-(C or T)-3' (PubMed:1258376). Also usually modifies adenine residues in the host cellular DNA (PubMed:1258376).<ref>PMID:1258376</ref> <ref>PMID:32369169</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia phage Mu]]
[[Category: Large Structures]]
[[Category: Bochtler M]]
[[Category: Guan C]]
[[Category: Lee YJ]]
[[Category: Lund SR]]
[[Category: Raleigh EA]]
[[Category: Silva RMB]]
[[Category: Skowronek K]]
[[Category: Slyvka A]]
[[Category: Weigele PR]]