View source for 8cyo


==Nurr1 Covalently Bound to a Synthetic Ligand, 10.25, via a Disulfide Bond==
<StructureSection load='8cyo' size='340' side='right'caption='[[8cyo]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CYO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OBJ:2-(3,4-dichlorophenoxy)-N-(2-sulfanylethyl)acetamide'>OBJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cyo OCA], [https://pdbe.org/8cyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cyo RCSB], [https://www.ebi.ac.uk/pdbsum/8cyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cyo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR4A2_HUMAN NR4A2_HUMAN] Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bruning JM]]
[[Category: England PM]]
[[Category: Liu J]]