View source for 8dye


==Crystal structure of human SDHA-SDHAF4 assembly intermediate==
<StructureSection load='8dye' size='340' side='right'caption='[[8dye]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DYE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.44&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dye OCA], [https://pdbe.org/8dye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dye RCSB], [https://www.ebi.ac.uk/pdbsum/8dye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dye ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SDHA_HUMAN SDHA_HUMAN] Familial isolated dilated cardiomyopathy;Hereditary pheochromocytoma-paraganglioma;Gastrointestinal stromal tumor;Isolated succinate-CoQ reductase deficiency. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SDHA_HUMAN SDHA_HUMAN] Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225).<ref>PMID:20484225</ref> <ref>PMID:24781757</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cecchini G]]
[[Category: Iverson TM]]
[[Category: Maklashina E]]
[[Category: Sharma P]]