View source for 8ght


==Cryo-electron microscopy structure of the zinc transporter from Bordetella bronchiseptica==
<StructureSection load='8ght' size='340' side='right'caption='[[8ght]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ght]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_bronchiseptica Bordetella bronchiseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GHT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ght FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ght OCA], [https://pdbe.org/8ght PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ght RCSB], [https://www.ebi.ac.uk/pdbsum/8ght PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ght ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZIP_BORBR ZIP_BORBR] Selective electrodiffusional channel that mediates the uptake of Zn(2+). Exploits in vivo zinc concentration gradients (maintained by cellular zinc homeostasis) to passively move zinc ions into the cytoplasm. ZIPB-mediated zinc flux is dependent upon pH, but independent of the proton motive force. Is also able to import Cd(2+), but is not permeable to Co(2+), Cu(2+), Fe(2+), Mn(2+) and Ni(2+).<ref>PMID:20876577</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bordetella bronchiseptica]]
[[Category: Large Structures]]
[[Category: Chai J]]
[[Category: Liu Q]]
[[Category: Pang CX]]
[[Category: Shanklin J]]