View source for 8i40


==Crystal structure of ASCT from Trypanosoma brucei in complex with CoA.==
<StructureSection load='8i40' size='340' side='right'caption='[[8i40]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8i40]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I40 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i40 OCA], [https://pdbe.org/8i40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i40 RCSB], [https://www.ebi.ac.uk/pdbsum/8i40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i40 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q386P1_TRYB2 Q386P1_TRYB2] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.[PIRNR:PIRNR000858]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Trypanosoma brucei brucei TREU927]]
[[Category: Balogun EO]]
[[Category: Boshart M]]
[[Category: Bringaud F]]
[[Category: Fukuda K]]
[[Category: Harada S]]
[[Category: Hirayama K]]
[[Category: Inaoka DK]]
[[Category: Iyoda K]]
[[Category: Kita K]]
[[Category: Kurasawa H]]
[[Category: Mazet M]]
[[Category: Millerioux Y]]
[[Category: Mochizuki K]]
[[Category: Nakai U]]
[[Category: Shiba T]]