View source for 8izs


==Structure of a triple-helix region of human collagen type XVII==
<StructureSection load='8izs' size='340' side='right'caption='[[8izs]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8izs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IZS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8izs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8izs OCA], [https://pdbe.org/8izs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8izs RCSB], [https://www.ebi.ac.uk/pdbsum/8izs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8izs ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/COHA1_HUMAN COHA1_HUMAN] Late-onset junctional epidermolysis bullosa;Intermediate generalized junctional epidermolysis bullosa;Epithelial recurrent erosion dystrophy;Localized junctional epidermolysis bullosa. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/COHA1_HUMAN COHA1_HUMAN] May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.  The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Sun F]]
[[Category: Yang X]]
[[Category: Zhu Y]]