View source for 8jbe


==CryoEM Structure of metazoan Mon1-Ccz1-RMC1 complex==
<StructureSection load='8jbe' size='340' side='right'caption='[[8jbe]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jbe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila Drosophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JBE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jbe OCA], [https://pdbe.org/8jbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jbe RCSB], [https://www.ebi.ac.uk/pdbsum/8jbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jbe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RMC1_DROME RMC1_DROME] Positive regulator of the Rab7 guanyl-nucleotide exchange activity of the Mon1-Ccz1 complex, possibly by enhancing its endosomal membrane association (PubMed:32391792, PubMed:32499409). As part of the Mon1-Ccz1 complex involved in endolysosomal biogenesis possibly by mediating Rab conversion, the replacement of Rab5 with Rab7 during late endosome maturation (PubMed:32499409).<ref>PMID:32391792</ref> <ref>PMID:32499409</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila]]
[[Category: Large Structures]]
[[Category: Jia D]]
[[Category: Jia GW]]
[[Category: Su ZM]]
[[Category: Yong X]]