View source for 8orj


==Cryo-EM structure of human tRNA ligase RTCB in complex with human PYROXD1.==
<StructureSection load='8orj' size='340' side='right'caption='[[8orj]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8orj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ORJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ORJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8orj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8orj OCA], [https://pdbe.org/8orj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8orj RCSB], [https://www.ebi.ac.uk/pdbsum/8orj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8orj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RTCB_HUMAN RTCB_HUMAN] Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.[HAMAP-Rule:MF_03144]<ref>PMID:21311021</ref> <ref>PMID:24870230</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ackle F]]
[[Category: Asanovic I]]
[[Category: Boneberg F]]
[[Category: Ferdigg A]]
[[Category: Jinek M]]
[[Category: Kroupova A]]
[[Category: Loeff L]]
[[Category: Martinez J]]
[[Category: Pfleiderer MM]]