View source for 8ou1


==Crystal structure of the SPOC domain of mouse SPOCD1==
<StructureSection load='8ou1' size='340' side='right'caption='[[8ou1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ou1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OU1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ou1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ou1 OCA], [https://pdbe.org/8ou1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ou1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ou1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ou1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPOC1_MOUSE SPOC1_MOUSE] Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32674113). Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (PubMed:32674113). Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1 (PubMed:32674113). Not required for piRNA biosynthesis (PubMed:32674113).<ref>PMID:32674113</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Cook AG]]
[[Category: Heep M]]
[[Category: O'Carroll D]]