View source for 8qmo


==Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex==
<StructureSection load='8qmo' size='340' side='right'caption='[[8qmo]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qmo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MOO:MOLYBDATE+ION'>MOO</scene>, <scene name='pdbligand=W62:benzo[a]pyrene'>W62</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qmo OCA], [https://pdbe.org/8qmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qmo RCSB], [https://www.ebi.ac.uk/pdbsum/8qmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qmo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ancelin A]]
[[Category: Bourguet W]]
[[Category: Carivenc C]]
[[Category: Grandvuillemin L]]
[[Category: Gruszczyk J]]
[[Category: Hesketh EL]]
[[Category: Kwong HS]]
[[Category: Lai-Kee-Him J]]
[[Category: Lancey C]]
[[Category: Ragan TJ]]
[[Category: Sirounian S]]