View source for 8snm


==Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain==
<StructureSection load='8snm' size='340' side='right'caption='[[8snm]], [[Resolution|resolution]] 3.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8snm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SNM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.84&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8snm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8snm OCA], [https://pdbe.org/8snm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8snm RCSB], [https://www.ebi.ac.uk/pdbsum/8snm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8snm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RHDF2_HUMAN RHDF2_HUMAN] Palmoplantar keratoderma-esophageal carcinoma syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/RHDF2_HUMAN RHDF2_HUMAN] Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.[UniProtKB:Q80WQ6]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dai Y]]
[[Category: Lee CH]]
[[Category: Wang Y]]
[[Category: Zhao H]]