View source for 8snp


==Crystal structure of mouse Netrin-1 in complex with samarium ions==
<StructureSection load='8snp' size='340' side='right'caption='[[8snp]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8snp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SNP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8snp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8snp OCA], [https://pdbe.org/8snp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8snp RCSB], [https://www.ebi.ac.uk/pdbsum/8snp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8snp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NET1_MOUSE NET1_MOUSE] Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Heide F]]
[[Category: Legare S]]
[[Category: Stetefeld J]]