View source for 8sxm


==NMR structure of the ZNF750 zinc finger domain, Z*==
<StructureSection load='8sxm' size='340' side='right'caption='[[8sxm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8sxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SXM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sxm OCA], [https://pdbe.org/8sxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sxm RCSB], [https://www.ebi.ac.uk/pdbsum/8sxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sxm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ZN750_HUMAN ZN750_HUMAN] Seborrhea-like dermatitis with psoriasiform elements. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ZN750_HUMAN ZN750_HUMAN] Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.<ref>PMID:22364861</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alexandrescu AT]]
[[Category: Rua AJ]]