View source for 8sxn


==Structure of NLRP3 and NEK7 complex==
<StructureSection load='8sxn' size='340' side='right'caption='[[8sxn]], [[Resolution|resolution]] 4.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8sxn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SXN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.04&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YN:1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea'>7YN</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sxn OCA], [https://pdbe.org/8sxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sxn RCSB], [https://www.ebi.ac.uk/pdbsum/8sxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sxn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEK7_HUMAN NEK7_HUMAN] Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.<ref>PMID:17101132</ref> <ref>PMID:17586473</ref> <ref>PMID:19414596</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bottelbergs A]]
[[Category: Grauwen K]]
[[Category: Haloi N]]
[[Category: Lindahl E]]
[[Category: Matico RE]]
[[Category: Miller R]]
[[Category: Oehlrich D]]
[[Category: Opdenbosch NV]]
[[Category: Perez-Benito L]]
[[Category: Pietrak B]]
[[Category: Schoubroeck BV]]
[[Category: Sharma S]]
[[Category: Suarez J]]
[[Category: Tresadern GJ]]
[[Category: Yin Y]]
[[Category: Yu X]]