View source for 8vhx


==Cryo-EM of neck of bacteriophage Chi==
<StructureSection load='8vhx' size='340' side='right'caption='[[8vhx]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vhx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chivirus_chi Chivirus chi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VHX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vhx OCA], [https://pdbe.org/8vhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vhx RCSB], [https://www.ebi.ac.uk/pdbsum/8vhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vhx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M9NTK8_9CAUD M9NTK8_9CAUD] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The flagellotropic bacteriophage chi (Chi) infects bacteria via the flagellar filament. Despite years of study, its structural architecture remains partly characterized. Through cryo-EM, we unveil chi's nearly complete structure, encompassing capsid, neck, tail, and tail tip. While the capsid and tail resemble phage YSD1, the neck and tail tip reveal new proteins and their arrangement. The neck shows a unique conformation of the tail tube protein, forming a socket-like structure for attachment to the neck. The tail tip comprises four proteins, including distal tail protein (DTP), two baseplate hub proteins (BH1P and BH2P), and tail tip assembly protein (TAP) exhibiting minimal organization compared to other siphophages. Deviating from the consensus in other siphophages, DTP in chi forms a trimeric assembly, reducing tail symmetry from 6-fold to 3-fold at the tip. These findings illuminate the previously unexplored structural organization of chi's neck and tail tip.

Cryo-EM structure of flagellotropic bacteriophage Chi.,Sonani RR, Esteves NC, Scharf BE, Egelman EH Structure. 2024 Jul 11;32(7):856-865.e3. doi: 10.1016/j.str.2024.03.011. Epub , 2024 Apr 12. PMID:38614087<ref>PMID:38614087</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8vhx" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chivirus chi]]
[[Category: Large Structures]]
[[Category: Egelman EH]]
[[Category: Esteves NC]]
[[Category: Scharf BE]]
[[Category: Sonani RR]]