View source for 8vu5


==Cryo-EM structure of MPL bound to TPO==
<StructureSection load='8vu5' size='340' side='right'caption='[[8vu5]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vu5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VU5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vu5 OCA], [https://pdbe.org/8vu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vu5 RCSB], [https://www.ebi.ac.uk/pdbsum/8vu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vu5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPO_MOUSE TPO_MOUSE] Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.[UniProtKB:P40225]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bratkowski M]]
[[Category: Hao Q]]
[[Category: Paddock M]]