View source for 8xwn


==Structure of CXCR2 bound to CXCL8 (Ligand-receptor focused map)==
<StructureSection load='8xwn' size='340' side='right'caption='[[8xwn]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xwn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XWN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xwn OCA], [https://pdbe.org/8xwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xwn RCSB], [https://www.ebi.ac.uk/pdbsum/8xwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xwn ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency. 
== Function ==
[https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Banerjee R]]
[[Category: Ganguly M]]
[[Category: Nureki O]]
[[Category: Saha S]]
[[Category: Sano FK]]
[[Category: Sharma S]]
[[Category: Shihoya W]]
[[Category: Shukla AK]]