View source for 9buc


==Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation (repeat)==
<StructureSection load='9buc' size='340' side='right'caption='[[9buc]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9buc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BUC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B90:icosanedioic+acid'>A1B90</scene>, <scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9buc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9buc OCA], [https://pdbe.org/9buc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9buc RCSB], [https://www.ebi.ac.uk/pdbsum/9buc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9buc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CALCR_HUMAN CALCR_HUMAN] This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Belousoff MJ]]
[[Category: Cao J]]
[[Category: Johnson RM]]
[[Category: Sexton PM]]
[[Category: Wootten DL]]