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==Solution structure of a silver ion mediated DNA duplex with universal 7-deazapurine substitutions==
<StructureSection load='9gdm' size='340' side='right'caption='[[9gdm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gdm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GDM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7DA:7-DEAZA-2-DEOXYADENOSINE-5-MONOPHOSPHATE'>7DA</scene>, <scene name='pdbligand=7GU:7-DEAZA-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>7GU</scene>, <scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gdm OCA], [https://pdbe.org/9gdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gdm RCSB], [https://www.ebi.ac.uk/pdbsum/9gdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gdm ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The challenge of transforming organized DNA structures into their metallized counterparts persists in the scientific field. In this context, utilizing DNA molecules modified with 7-deazapurine, provides a transformative solution. In this study, we present the solution structure of a DNA duplex that can be transformed into its metallized equivalent while retaining the natural base pairing arrangement through the creation of silver-modified Watson-Crick base pairs. Unlike previously documented X-ray structures, our research demonstrates the feasibility of preserving the intrinsic DNA self-assembly while incorporating Ag(I) into the double helix, illustrating that the binding of silver does not disrupt the canonical base-pairing organization. Moreover, in our case, the uninterrupted Ag(I) chain deviates from forming conventional straight linear chains; instead, it adheres to a helical arrangement dictated by the underlying DNA structure. This research challenges conventional assumptions and opens the door to precisely design structures based on the organization of highly stable Ag-DNA assemblies.

Unveiling the solution structure of a DNA duplex with continuous silver-modified Watson-Crick base pairs.,Javornik U, Perez-Romero A, Lopez-Chamorro C, Smith RM, Dobado JA, Palacios O, Bera MK, Nyman M, Plavec J, Galindo MA Nat Commun. 2024 Sep 5;15(1):7763. doi: 10.1038/s41467-024-51876-8. PMID:39237564<ref>PMID:39237564</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Galindo MA]]
[[Category: Javornik U]]
[[Category: Plavec J]]