View source for 9hjt


==Structure of Zincore (SEPHS1:QRICH1) binding to ZFP91 on DNA==
<StructureSection load='9hjt' size='340' side='right'caption='[[9hjt]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hjt]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HJT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.26&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hjt OCA], [https://pdbe.org/9hjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hjt RCSB], [https://www.ebi.ac.uk/pdbsum/9hjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hjt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZFP91_HUMAN ZFP91_HUMAN] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.<ref>PMID:12738986</ref> <ref>PMID:20682767</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Borza R]]
[[Category: Perrakis A]]