View source for 9igs


==Mouse teneurin-3 A1B1 isoform; microphthalmia-associated R2579W mutant; compact dimer conformation==
<StructureSection load='9igs' size='340' side='right'caption='[[9igs]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9igs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IGS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9igs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9igs OCA], [https://pdbe.org/9igs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9igs RCSB], [https://www.ebi.ac.uk/pdbsum/9igs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9igs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TEN3_MOUSE TEN3_MOUSE] Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:17478416, PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022, PubMed:29414938). Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (PubMed:29414938). Promotes homophilic adhesion in a splicing isoform-dependent manner: most isoforms (isoform-type A and type-B) can mediate homophilic interaction (PubMed:29414938). Promotes axon guidance (PubMed:23028443). Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway (PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022). Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) (PubMed:17803360, PubMed:23028443). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes (PubMed:20636325).<ref>PMID:17478416</ref> <ref>PMID:17803360</ref> <ref>PMID:20636325</ref> <ref>PMID:22499796</ref> <ref>PMID:23028443</ref> <ref>PMID:25406022</ref> <ref>PMID:29414938</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Gogou C]]
[[Category: Meijer DH]]