View source for 9ijw


==Serine protease inhibitor HCIQ2c1 from Heteractis crispa with TRPA1 mediated antinociceptive activity==
<StructureSection load='9ijw' size='340' side='right'caption='[[9ijw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ijw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Radianthus_crispa Radianthus crispa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IJW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ijw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ijw OCA], [https://pdbe.org/9ijw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ijw RCSB], [https://www.ebi.ac.uk/pdbsum/9ijw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ijw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VKT2I_RADCR VKT2I_RADCR] Serine protease inhibitor that also shows protective effect in a cytotoxicity model (PubMed:32144281). It binds to all proteases tested (trypsin (Ki=52 nM), alpha-chymotrypsin, cathepsin G, kallikrein, and human neutrophil elastase) (PubMed:32144281). It significantly increases neuroblastoma cell viability in an in vitro neurotoxicity model, being a consequence of an effective decrease of reactive oxygen species (ROS) level in the cells (PubMed:32144281, PubMed:35563513). It also seems to protect cells by inhibiting ATP-induced purinoceptor (P2RX7) activation (PubMed:35563513).<ref>PMID:32144281</ref> <ref>PMID:35563513</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Radianthus crispa]]
[[Category: Leychenko EV]]
[[Category: Lyukmanova EN]]
[[Category: Menshov AS]]
[[Category: Mironov PA]]
[[Category: Oreshkov SD]]
[[Category: Paramonov AS]]
[[Category: Shenkarev ZO]]