View source for 9kh2


==Crystal structure of the first three zinc finger domains of ZBTB20 in complex with DNA==
<StructureSection load='9kh2' size='340' side='right'caption='[[9kh2]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kh2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KH2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kh2 OCA], [https://pdbe.org/9kh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kh2 RCSB], [https://www.ebi.ac.uk/pdbsum/9kh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kh2 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ZBT20_HUMAN ZBT20_HUMAN] Intellectual disability-cataracts-calcified pinnae-myopathy syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ZBT20_HUMAN ZBT20_HUMAN] May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).[UniProtKB:Q8K0L9]<ref>PMID:11352661</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Chen X]]
[[Category: Duan B]]
[[Category: Luo Z]]
[[Category: Song Y]]
[[Category: Wu J]]
[[Category: Xu S]]