View source for 9kk3


==Solution structure of kappa-conotoxin RIIIK==
<StructureSection load='9kk3' size='340' side='right'caption='[[9kk3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_radiatus Conus radiatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KK3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kk3 OCA], [https://pdbe.org/9kk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kk3 RCSB], [https://www.ebi.ac.uk/pdbsum/9kk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kk3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CM3K_CONRA CM3K_CONRA] Kappa-conotoxins inhibits voltage-gated potassium channels (Kv). This synthetic toxin reversibly inhibits the insect potassium channel Shaker K+, the teleost homolog TSha1 and the mammalian Kv1.2/KCNA2 channel. Interacts with the pore region of the insect channel, in a state-dependent manner. Causes seizure when intracerebrovascularly injected into mice. Is also toxic when intrathecally injected into mice, but shows no visible effects by intraperitoneal injection. Shows protective effects on cardiac tissue when administered after an ischemic event.<ref>PMID:12399472</ref> <ref>PMID:20220134</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Conus radiatus]]
[[Category: Large Structures]]
[[Category: Bocharov EV]]
[[Category: Lushpa VA]]
[[Category: Olivera BM]]
[[Category: Raghuraman S]]
[[Category: Rivier J]]
[[Category: Vassilevski AA]]