View source for 9kkj


==Structure of Nectin-4 D1 domain in complex with the Fab fragment of 9MW2821 mAb==
<StructureSection load='9kkj' size='340' side='right'caption='[[9kkj]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kkj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KKJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.26&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kkj OCA], [https://pdbe.org/9kkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kkj RCSB], [https://www.ebi.ac.uk/pdbsum/9kkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kkj ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Ectodermal dysplasia-pili torti-cutaneous syndactyly syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.  (Microbial infection) Acts as a receptor for measles virus.<ref>PMID:22048310</ref> <ref>PMID:23202587</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Wen HY]]