View source for 9mnn


==Crystal structure of L. monocytogenes MenD with Mg2+ and intermediate I bound==
<StructureSection load='9mnn' size='340' side='right'caption='[[9mnn]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mnn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_10403S Listeria monocytogenes 10403S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MNN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TD6:(4S)-4-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3LAMBDA~5~-THIAZOL-2-YL}-4-HYDROXYBUTANOIC+ACID'>TD6</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mnn OCA], [https://pdbe.org/9mnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mnn RCSB], [https://www.ebi.ac.uk/pdbsum/9mnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mnn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H3GD77_LISM4 A0A0H3GD77_LISM4] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).[HAMAP-Rule:MF_01659]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Listeria monocytogenes 10403S]]
[[Category: Allison TM]]
[[Category: Given FM]]
[[Category: Ho NAT]]
[[Category: Johnston JM]]
[[Category: Klein M]]