View source for 9nea


==Human polymerase epsilon bound to PCNA and DNA with a pre-existing mismatch in the blocked conformation II==
<StructureSection load='9nea' size='340' side='right'caption='[[9nea]], [[Resolution|resolution]] 3.81&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nea]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NEA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.81&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PST:THYMIDINE-5-THIOPHOSPHATE'>PST</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nea OCA], [https://pdbe.org/9nea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nea RCSB], [https://www.ebi.ac.uk/pdbsum/9nea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nea ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DPOE1_HUMAN DPOE1_HUMAN] Facial dysmorphism - immunodeficiency - livedo - short stature. Disease susceptibility is associated with variations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DPOE1_HUMAN DPOE1_HUMAN] Participates in DNA repair and in chromosomal DNA replication.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: He Q]]
[[Category: Li H]]
[[Category: Wang F]]