View source for 9oyo


==Structure of R15L D10-NT amyloid fibrils==
<StructureSection load='9oyo' size='340' side='right'caption='[[9oyo]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9oyo]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OYO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9oyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9oyo OCA], [https://pdbe.org/9oyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9oyo RCSB], [https://www.ebi.ac.uk/pdbsum/9oyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9oyo ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CHC10_HUMAN CHC10_HUMAN] Frontotemporal dementia with motor neuron disease;Autosomal dominant mitochondrial myopathy with exercise intolerance;Amyotrophic lateral sclerosis;Lower motor neuron syndrome with late-adult onset. The disease is caused by variants affecting the gene represented in this entry. The pathological events leading to disease involve fragmentation of the mitochondrial network, mitochondrial ultrastructural abnormalities including loss, disorganization and dilatation of cristae, and mitochondrial dysfunction associated with respiratory chain deficiency (PubMed:24934289).<ref>PMID:24934289</ref>   The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CHC10_HUMAN CHC10_HUMAN] May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.<ref>PMID:24934289</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Eliezer D]]
[[Category: Lv G]]