View source for 9ppu


==Beta-sandwich forming metallopeptide==
<StructureSection load='9ppu' size='340' side='right'caption='[[9ppu]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ppu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PPU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACA:6-AMINOHEXANOIC+ACID'>ACA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ppu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ppu OCA], [https://pdbe.org/9ppu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ppu RCSB], [https://www.ebi.ac.uk/pdbsum/9ppu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ppu ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The active site of multicopper oxidases contains three Cu ions coordinated to a beta-sandwich motif. Here, we designed a small peptide ligand that closely mimics the beta-sandwich. We verified the sandwich architecture by X-ray crystallography, showing its high resemblance to the active site and ability to coordinate two Cu(II) ions.

A bis-macrocylic peptide ligand mimicking the beta-sandwich active site of multicopper oxidases.,Dang VT, Drena A, Telser J, Wofford L, Nguyen AI Dalton Trans. 2026 Apr 21;55(15):5877-5881. doi: 10.1039/d6dt00494f. PMID:41969027<ref>PMID:41969027</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9ppu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Dang VT]]
[[Category: Nguyen AI]]