View source for 9qqs


==Structure of the MEGF8-MOSMO complex with nanobody 270 (Focused refinement)==
<StructureSection load='9qqs' size='340' side='right'caption='[[9qqs]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9qqs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QQS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JAX:(1~{S},2~{S},4~{S},5~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-16-methoxy-5,7,9,13-tetramethyl-spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2-oxane]'>A1JAX</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qqs OCA], [https://pdbe.org/9qqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qqs RCSB], [https://www.ebi.ac.uk/pdbsum/9qqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qqs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MOSMO_HUMAN MOSMO_HUMAN] Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation.[UniProtKB:Q8C784]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Bazan F]]
[[Category: Carrique L]]
[[Category: Chalk R]]
[[Category: Gao L]]
[[Category: Hedger G]]
[[Category: Kong JH]]
[[Category: Lartey D]]
[[Category: Latorraca NR]]
[[Category: Marqusee S]]
[[Category: Milenkovic L]]
[[Category: Nocka LM]]
[[Category: Parashara P]]
[[Category: Pardon E]]
[[Category: Pusapati GV]]
[[Category: Rohatgi R]]
[[Category: Rouse SL]]
[[Category: Sarkar P]]
[[Category: Siebold C]]
[[Category: Steyaert J]]
[[Category: Williams C]]