View source for 9sng


==CTLH-CRA domain of murine RanBP10 mutant Q519G, F543L, Y548F and V556F==
<StructureSection load='9sng' size='340' side='right'caption='[[9sng]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9sng]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SNG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sng OCA], [https://pdbe.org/9sng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sng RCSB], [https://www.ebi.ac.uk/pdbsum/9sng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sng ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBP10_MOUSE RBP10_MOUSE] May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.<ref>PMID:18347012</ref> <ref>PMID:19801445</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Schindelin H]]
[[Category: Van gen Hassend PM]]