View source for 9snt


==Apo-form of Schistosoma mansoni Cathepsin D1 at 2.2A resolution==
<StructureSection load='9snt' size='340' side='right'caption='[[9snt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9snt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SNT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9snt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9snt OCA], [https://pdbe.org/9snt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9snt RCSB], [https://www.ebi.ac.uk/pdbsum/9snt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9snt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G4VEV6_SCHMA G4VEV6_SCHMA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino-acid source for the developing parasite. Therefore, the enzyme is a potential target for the development of antischistosomal inhibitors. SmCD1 has significant sequence identity to cathepsin D-like proteases found in other schistosome species and homology to mammalian aspartic proteases. Here, we report the first crystal structures of a helminth cathepsin D, SmCD1, and have identified a single-domain antibody (nanobody) that specifically binds to SmCD1 with nanomolar affinity but does not recognize human cathepsin D. We have mapped the epitope of the nanobody by determining the crystal structure of the enzyme-nanobody complex, revealing the conformation of SmCD1 in the propeptide-bound state.

Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide-bound state.,Parker KL, Clarke JD, Liu X, Gomes BF, Eyssen LEA, Furnham N, Paes Silva-Jr F, Owens RJ Acta Crystallogr D Struct Biol. 2026 Feb 1;82(Pt 2):140-150. doi: , 10.1107/S2059798326000422. Epub 2026 Jan 28. PMID:41603320<ref>PMID:41603320</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9snt" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schistosoma mansoni]]
[[Category: Clarke JD]]
[[Category: Eyssen LE]]
[[Category: Furnham N]]
[[Category: Gomes BF]]
[[Category: Liu X]]
[[Category: Owens RJ]]
[[Category: Parker K]]
[[Category: Silva-Jr FP]]