View source for 9srk


==Structure of collectin-11 (CL-11) carbohydrate-recognition domain in complex with L-fucose==
<StructureSection load='9srk' size='340' side='right'caption='[[9srk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9srk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SRK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9srk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9srk OCA], [https://pdbe.org/9srk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9srk RCSB], [https://www.ebi.ac.uk/pdbsum/9srk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9srk ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/COL11_HUMAN COL11_HUMAN] Craniofacial-ulnar-renal syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/COL11_HUMAN COL11_HUMAN] Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
SARS-CoV-2 respiratory-tract infection affects both vaccinated and unvaccinated persons suggesting factors besides adaptive immunity are operative. We investigated the role of collectin-11 (CL-11), an epithelial-secreted carbohydrate-binding lectin that drives innate immunity and eliminates pathogens by complement activation. SARS-CoV-2, despite binding CL-11 to activate complement, was resistant to lysis. Remarkably, opsonization by CL-11 enhanced virus production by infected respiratory epithelial cells independently of complement. Furthermore, infected cells expressing SARS-CoV-2 spike protein displayed enhanced vulnerability to CL-11 binding and membrane attack by complement. The mechanism of enhanced infectivity was ablated in the presence of L-fucose, which occupied the extended carbohydrate-binding cleft of CL-11 in a crystallographic analysis of complexes between L-fucose and CL-11. Our study suggests pathogenicity of SARS-CoV-2 is related to complement-resistance together with enhanced infectivity and injury of respiratory epithelial cells mediated by locally released CL-11.

Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells.,Polycarpou A, Wagner-Gamble T, Greenlaw R, O'Neill L, Kanabar V, Alrehaili A, Jeon Y, Baker J, Bafadhel M, Khan H, Malim MH, Romano M, Farrar CA, Smolarek D, Martinez-Nunez R, Doores KJ, Wallis R, Klavinskis LS, Sacks SH Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2521209122. doi: , 10.1073/pnas.2521209122. Epub 2025 Oct 24. PMID:41134631<ref>PMID:41134631</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9srk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alrehaili AFM]]
[[Category: Sacks SH]]
[[Category: Wallis R]]
[[Category: Klavinskis LS]]