View source for 9vm7


==Structure of DOCK6 tetramer complexed with Rac1==
<StructureSection load='9vm7' size='340' side='right'caption='[[9vm7]], [[Resolution|resolution]] 6.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9vm7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VM7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vm7 OCA], [https://pdbe.org/9vm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vm7 RCSB], [https://www.ebi.ac.uk/pdbsum/9vm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vm7 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DOCK6_HUMAN DOCK6_HUMAN] Adams-Oliver syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DOCK6_HUMAN DOCK6_HUMAN] Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).<ref>PMID:17196961</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hanada K]]
[[Category: Ishizuka-Katsura Y]]
[[Category: Katsura K]]
[[Category: Kukimoto-Niino M]]
[[Category: Shirouzu M]]
[[Category: Yonemochi M]]