View source for 9x02


==Crystal structure of human type VII collagen vWFA2 domain in complex with homo-trimeric collagen model peptide.==
<StructureSection load='9x02' size='340' side='right'caption='[[9x02]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9x02]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9X02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9X02 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=KLF:(2~{S},4~{R})-4-oxidanylpyrrolidine-2-carboxamide'>KLF</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9x02 OCA], [https://pdbe.org/9x02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9x02 RCSB], [https://www.ebi.ac.uk/pdbsum/9x02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9x02 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CO7A1_HUMAN CO7A1_HUMAN] Self-improving dystrophic epidermolysis bullosa;Localized dystrophic epidermolysis bullosa, nails only;Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form;Localized dystrophic epidermolysis bullosa, pretibial form;Autosomal dominant generalized dystrophic epidermolysis bullosa;Localized dystrophic epidermolysis bullosa, acral form;Dystrophic epidermolysis bullosa pruriginosa;Autosomal recessive generalized dystrophic epidermolysis bullosa, severe form;Recessive dystrophic epidermolysis bullosa inversa. Epidermolysis bullosa acquisita (EBA) is an autoimmune acquired blistering skin disease resulting from autoantibodies to type VII collagen.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CO7A1_HUMAN CO7A1_HUMAN] Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fujii K]]
[[Category: Hashimoto M]]
[[Category: Kawahara K]]
[[Category: Koide T]]
[[Category: Oki H]]