View source for 9yi4


==Octopus sensory receptor CRT1 bound to Progesterone==
<StructureSection load='9yi4' size='340' side='right'caption='[[9yi4]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9yi4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Octopus_bimaculoides Octopus bimaculoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YI4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yi4 OCA], [https://pdbe.org/9yi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yi4 RCSB], [https://www.ebi.ac.uk/pdbsum/9yi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yi4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRT1_OCTBM CRT1_OCTBM] Chemotactile receptors that mediate contact-dependent chemosensation in cephalopods, allowing them to respond to stimuli in the marine environment (PubMed:33125889, PubMed:37045917, PubMed:37045920, PubMed:40532695). Enriched in the suction cups on the arms, they elicit robust autonomous movement and modify predatory and maternal behavior upon activation (PubMed:37045920, PubMed:40532695). Permeable to cations including sodium, potassium and calcium ions (PubMed:33125889, PubMed:37045920, PubMed:40532695). Binds a wide range of hydrophobic agonists, but the extent of receptor activation is modulated by the electronegativity of the ligands (PubMed:37045920, PubMed:40532695).<ref>PMID:33125889</ref> <ref>PMID:37045917</ref> <ref>PMID:37045920</ref> <ref>PMID:40532695</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Octopus bimaculoides]]
[[Category: Hibbs RE]]
[[Category: Jiang H]]