View source for 9yl3


==State 1 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac==
<StructureSection load='9yl3' size='340' side='right'caption='[[9yl3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9yl3]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YL3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yl3 OCA], [https://pdbe.org/9yl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yl3 RCSB], [https://www.ebi.ac.uk/pdbsum/9yl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yl3 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.<ref>PMID:16603732</ref> <ref>PMID:17500065</ref> <ref>PMID:17851529</ref> [https://www.uniprot.org/uniprot/A0A6P6IDI8_PUMCO A0A6P6IDI8_PUMCO] 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Roeder R]]
[[Category: Sun J]]