View source for 9zhh


==Cryo-EM structure of IGFBP7 dodecamer. The 3D refinement was focused on the central part of the dodecamer, which contains 12 IgC2 domains.==
<StructureSection load='9zhh' size='340' side='right'caption='[[9zhh]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9zhh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZHH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zhh OCA], [https://pdbe.org/9zhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zhh RCSB], [https://www.ebi.ac.uk/pdbsum/9zhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zhh ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IBP7_HUMAN IBP7_HUMAN] Familial retinal arterial macroaneurysm. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/IBP7_HUMAN IBP7_HUMAN] Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.<ref>PMID:8117260</ref> <ref>PMID:8939990</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bai XC]]
[[Category: Cai K]]
[[Category: Zhang XW]]