View source for Apoptosis-inducing factor

<StructureSection load='' size='450' side='right' caption='Human apoptosis-inducing factor complex with FAD, NAD and sulfate (PDB code [[4bur]])' scene='74/749463/Cv/1'>

== Function ==
'''Apoptosis-inducing factor''' (AIF) is an intermembrane flavoprotein which induces caspase-independent peripheral chromatin condensation and large-scale DNA fragmentation and thus causes cell death<ref>PMID:12022952</ref>.  AIF contains the cofactor FAD.

== Relevance ==
AIF deficiency is a risk factor for the development of diabetic kidney disease<ref>PMID:26822084</ref>.

== Structural highlights ==
The AIF binding site contains the cofactor <scene name='74/749463/Cv/2'>FAD</scene> and 2 molecules of the reducing factor NADH<ref>PMID:24914854</ref>. Water molecules shown as red spheres.
*<scene name='74/749463/Cv/3'>1st NADH binding site</scene>.
*<scene name='74/749463/Cv/4'>2nd NADH binding site</scene>.
*<scene name='74/749463/Cv/5'>FAD/1st molecule NADF tunnel</scene>.
*<scene name='74/749463/Cv/6'>2nd NADH binding site in surface representation</scene>.

</StructureSection>
==3D structures of apoptosis-inducing factor see CED-8 in [[Cell death protein]]==


== References ==
<references/>
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